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Title   위암 및 인접 점막의 DNA Ploidy 형태 ( DNA Ploidy of Gastric Cancer and it's Adjacent Mucose )
Publicationinfo   1992 Jan; 024(02): 227-233.
Key_word   Gastric cancer, Mucosa, DNA ploidy
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Abstract   Gastric tumors with a narrow DNA dispersion are related to a low malignant potential, whereas those with widely scattered DNA dispersion are linked to a high malignancy. The authors measured the nuclear DNA content and carried out analysis of ploidy in gastric cancer cells and normal adjacent mucosal cells using fresh specimens from tissues obtained in resected 25 gastric cancers by means of DNA flow cytometer. The results showed that 9 cases(36%) were diploid(type I), 5 cases(20%) were tetraploid(type II), 8 cases(32%) were aneuploid(type III), and 3 cases(12%) were multiploid(type IV). The mean value of the S-phase ce11s were 19.1%. The nuclear patterns had correlation with the depth of tumor invasion, but the DNA patterns had no significant correlation to location, size and histologic type of tumor. Type III and IV were frequently found in distant metastasis and type I and II were frequently found in cases without lymph node metastasis. We found one case with type II ploid pattern from the normally appearing mucosa adjacent to the type III gastric cancer. The results of this study show that flow cytometric measurement of nuclear DNA is considered one method of determining the biological activity of gastric cancer celL DNA ploidy of tumor cells provides a reliable indicator of prognosis for patients with gastric carcinoma. Abnormal ploidy pattenrn of adjacent mucosa suggest the carcinogenic promotional events are widespread in the gastric mucosa in certain cases.
저 자   김동의(Dong Yi Kim),조철균(Chol Gyoon Cho),조영국(Young Kook Cho)